What the FDA labels say about taking them together
Aminophylline and diazepam
Aminophylline's FDA label of May 22, 2026 names diazepam in its drug interactions section; the diazepam labels PlainMeds reads (4) do not name aminophylline. The aminophylline label: “25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.”
Check it at the source: the aminophylline FDA label on DailyMed (effective May 22, 2026, Hospira, Inc.); the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC).
What does the aminophylline label say about diazepam?
Aminophylline label, drug interactions25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.
Source: FDA drug label (Aminophylline), Hospira, Inc., effective May 22, 2026 (SPL set 9a663ef3-881f-48bd-2689-3713b24545c2), via openFDA; the full label on DailyMed
What does the diazepam label say about aminophylline?
Diazepam's label (effective August 11, 2026) and its 3 other brand-application labels do not name aminophylline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aminophylline | Diazepam | |
|---|---|---|
| Labeled for | Asthma | Anxiety, Muscle spasms and spasticity |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0283 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once