What the FDA labels say about taking them together
Aminolevulinic acid and griseofulvin
Aminolevulinic acid's FDA label of January 29, 2026 names griseofulvin in its drug interactions section; the griseofulvin label PlainMeds reads does not name aminolevulinic acid. The aminolevulinic acid label: “Due to the risk of phototoxic reactions, do not administer phototoxic drugs, and topical preparations containing ALA for 24 hours during the perioperative period.”
Check it at the source: the aminolevulinic acid FDA label on DailyMed (effective January 29, 2026, NX DEVELOPMENT CORP); the griseofulvin FDA label on DailyMed (effective December 10, 2025).
What does the aminolevulinic acid label say about griseofulvin?
Aminolevulinic acid label, drug interactionsDue to the risk of possible phototoxic reactions, avoid administering phototoxic drugs such as St. John's wort, griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulphonamides, quinolones and tetracyclines, and topical preparations containing ALA for 24 hours before and after administration of Gleolan.
Aminolevulinic acid label, warnings and precautionsDue to the risk of phototoxic reactions, do not administer phototoxic drugs (St. John's wort, griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulphonamides, quinolones and tetracyclines), and topical preparations containing ALA for 24 hours during the perioperative period [see Drug Interactions (7) ].
Levulan Kerastick label (Sun Pharmaceutical Industries, Inc, September 12, 2024), drug interactionsIt is, however, possible that concomitant use of other known photosensitizing agents such as St. John’s wort, griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulfonamides and tetracyclines might increase the photosensitivity reaction of actinic keratoses treated with LEVULAN KERASTICK topical solution [see Warnings and Precautions (5.2) ].
Ameluz label (Biofrontera Inc., August 26, 2026), drug interactionsIt is possible that concomitant use of other known photosensitizing agents such as St. John’s wort, griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulphonamides, quinolones and tetracyclines may enhance the phototoxic reaction to PDT [see Warnings and Precautions (5.3) ].
Source: FDA drug label (Levulan Kerastick, NDA020965), Sun Pharmaceutical Industries, Inc, effective September 12, 2024 (SPL set e45cc371-9ebc-4904-12bc-65cb4e2817ad), via openFDA
Source: FDA drug label (Ameluz, NDA208081), Biofrontera Inc., effective August 26, 2026 (SPL set 650daa9f-aeec-49ce-95b9-5fa20b988afd), via openFDA
Source: FDA drug label (GLEOLAN), NDA208630 (Nxdc), as published by NX DEVELOPMENT CORP, effective January 29, 2026 (SPL set cdeded66-0017-42cf-9471-13f231014323), via openFDA; the full label on DailyMed
What does the griseofulvin label say about aminolevulinic acid?
Griseofulvin's label (effective December 10, 2025) does not name aminolevulinic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ultramicrosize Griseofulvin), Chartwell RX, LLC., effective December 10, 2025 (SPL set efb8a660-802c-4ca6-bbff-ad7b48b91aef), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aminolevulinic acid | Griseofulvin | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $3.74 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once