Amikacin and Piperacillin/Tazobactam Interaction
Drug interaction information between Amikacin and Piperacillin/Tazobactam.
Amikacin and Piperacillin/Tazobactam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amikacin and Piperacillin/Tazobactam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs can be given through the same IV line at the same time as long as they are mixed in specific liquids and at certain strengths.
FDA Label Information
ZOSYN, which contains EDTA, is compatible with amikacin and gentamicin for simultaneous Y-site infusion in certain diluents and at specific concentrations.
Piperacillin/Tazobactam Also Interacts With
- Probenecid moderate
- Methotrexate minor
- Vancomycin minor
- Gentamicin minor
- Tobramycin minor
Frequently Asked Questions
What SPL severity band is on file for Amikacin + Piperacillin/Tazobactam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Piperacillin/Tazobactam has 7 labeled pairs on file vs Amikacin's 2. In the minor band specifically: Amikacin has 1; Piperacillin/Tazobactam has 6 (also Methotrexate, Vancomycin, Gentamicin, Tobramycin).
What mechanism field is on file for Amikacin and Piperacillin/Tazobactam?
These two drugs can be given through the same IV line at the same time as long as they are mixed in specific liquids and at certain strengths.
Amikacin carries more major-labeled pairs than Piperacillin/Tazobactam
SPL source-record counts only. This page's band is minor · classes on file: Amikacin (Aminoglycoside Antibiotic); Piperacillin/Tazobactam (Penicillin / Beta-Lactamase Inhibitor).
Amikacin has 1 major-labeled pair vs Piperacillin/Tazobactam's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 1 minor · 2 total
Amikacin has no other minor-band peer in this dataset besides Piperacillin/Tazobactam.
0 major · 1 moderate · 6 minor · 7 total
- Other minor peers for Piperacillin/Tazobactam
- Methotrexate
- Vancomycin
- Gentamicin
- Tobramycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.