What the FDA labels say about taking them together
Amantadine and memantine
Memantine's FDA label of November 1, 2018 names amantadine in its drug interactions section; the amantadine labels PlainMeds reads (2) do not name memantine.
Check it at the source: the amantadine FDA label on DailyMed (effective January 30, 2026, Strides Pharma Inc.); the memantine FDA label on DailyMed (effective November 1, 2018, Actavis Pharma, Inc.).
What does the amantadine label say about memantine?
Amantadine's label (effective January 30, 2026) and its 1 other brand-application label do not name memantine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amantadine Hydrochloride), Strides Pharma Inc., effective January 30, 2026 (SPL set e4d8f36f-d668-4728-8dca-b1c22bd9aedb), via openFDA; the full label on DailyMed
What does the memantine label say about amantadine?
Memantine label, drug interactionsUse with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution.
Source: FDA drug label (memantine hydrochloride), NDA021487 (Abbvie), as published by Actavis Pharma, Inc., effective November 1, 2018 (SPL set 72973b46-f307-4a9e-8fb1-ad2cbccfd736), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amantadine | Memantine | |
|---|---|---|
| Labeled for | Influenza, Parkinson's disease | Alzheimer's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.143 per capsule 100 mg capsule | $0.063 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once