What the FDA labels say about taking them together
Amantadine and dicyclomine
Dicyclomine's FDA label of August 6, 2026 names amantadine in its drug interactions section; the amantadine labels PlainMeds reads (2) do not name dicyclomine. The dicyclomine label: “Drugs with Anticholinergic Activity The following agents may increase certain actions or side effects of anticholinergic drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g. …”
Check it at the source: the amantadine FDA label on DailyMed (effective January 30, 2026, Strides Pharma Inc.); the dicyclomine FDA label on DailyMed (effective August 6, 2026, Lannett Company, LLC).
What does the amantadine label say about dicyclomine?
Amantadine's label (effective January 30, 2026) and its 1 other brand-application label do not name dicyclomine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amantadine Hydrochloride), Strides Pharma Inc., effective January 30, 2026 (SPL set e4d8f36f-d668-4728-8dca-b1c22bd9aedb), via openFDA; the full label on DailyMed
What does the dicyclomine label say about amantadine?
Dicyclomine label, drug interactionsDrugs with Anticholinergic Activity The following agents may increase certain actions or side effects of anticholinergic drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity.
Source: FDA drug label (Dicyclomine Hydrochloride), Lannett Company, LLC, effective August 6, 2026 (SPL set bd2cba10-70ec-4d1f-b46c-53d1de2ee130), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amantadine | Dicyclomine | |
|---|---|---|
| Labeled for | Influenza, Parkinson's disease | Irritable bowel syndrome |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.143 per capsule 100 mg capsule | $0.059 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once