What the FDA labels say about taking them together
Alteplase and epinephrine
Alteplase's FDA label of January 20, 2026 names epinephrine in its warnings and precautions section; the epinephrine labels PlainMeds reads (4) do not name alteplase.
Check it at the source: the alteplase FDA label on DailyMed (effective January 20, 2026, Genentech, Inc.); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the alteplase label say about epinephrine?
Alteplase label, warnings and precautionsIf signs of hypersensitivity occur, e.g. anaphylactoid reaction or angioedema develops, discontinue the Activase infusion and promptly institute appropriate therapy (e.g., antihistamines, intravenous corticosteroids, epinephrine).
Source: FDA drug label (Activase), Genentech, Inc., effective January 20, 2026 (SPL set c669f77c-fa48-478b-a14b-80b20a0139c2), via openFDA; the full label on DailyMed
What does the epinephrine label say about alteplase?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name alteplase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alteplase | Epinephrine | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Blood clots (DVT and PE) | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $186.38 per vial 2 mg vial | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once