What the FDA labels say about taking them together
Alteplase and aspirin
Alteplase's FDA label of January 20, 2026 names aspirin in its warnings and precautions section; the aspirin label PlainMeds reads does not name alteplase. The alteplase label: “Because heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites.”
Check it at the source: the alteplase FDA label on DailyMed (effective January 20, 2026, Genentech, Inc.); the aspirin FDA label on DailyMed (effective September 9, 2025).
What does the alteplase label say about aspirin?
Alteplase label, warnings and precautionsBecause heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites.
Source: FDA drug label (Activase), Genentech, Inc., effective January 20, 2026 (SPL set c669f77c-fa48-478b-a14b-80b20a0139c2), via openFDA; the full label on DailyMed
What does the aspirin label say about alteplase?
Aspirin's label (effective September 9, 2025) does not name alteplase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alteplase | Aspirin | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Blood clots (DVT and PE) | Pain, Cough and cold, Fever |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $186.38 per vial 2 mg vial | $0.0142 per tablet 81 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once