What the FDA labels say about taking them together
Alprostadil and heparin
Alprostadil's FDA label of March 27, 2024 names heparin in its drug interactions section; the heparin labels PlainMeds reads (4) do not name alprostadil. The alprostadil label: “Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin.”
Check it at the source: the alprostadil FDA label on DailyMed (effective March 27, 2024, Endo USA, Inc.); the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC).
What does the alprostadil label say about heparin?
Alprostadil label, drug interactionsTherefore, caution should be exercised with concomitant administration of heparin and edex ® . (Also, see Drug-Drug Interactions in CLINICAL PHARMACOLOGY, Pharmacokinetics .)
Caverject label (Pharmacia & Upjohn Company LLC, May 13, 2024), warnings and precautionsInjection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin.
Source: FDA drug label (Caverject, NDA020379), Pharmacia & Upjohn Company LLC, effective May 13, 2024 (SPL set a295fc1e-d82c-4f44-bc2d-a552bf594c98), via openFDA
Source: FDA drug label (Edex), Endo USA, Inc., effective March 27, 2024 (SPL set e8b8ec8d-1318-43e4-a182-446e9f9579de), via openFDA; the full label on DailyMed
What does the heparin label say about alprostadil?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name alprostadil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprostadil | Heparin | |
|---|---|---|
| Labeled for | Erectile dysfunction | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $106.24 per kit 20 mcg kit | $1.18 per mL 5,000 unit/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once