What the FDA labels say about taking them together
Alprazolam and nefazodone
Alprazolam's FDA label of January 18, 2023 names nefazodone in its drug interactions section, and nefazodone's label names alprazolam too. The nefazodone label: “Interaction with Triazolobenzodiazepines Interaction studies of nefazodone with two triazolobenzodiazepines, i.e., triazolam and alprazolam, metabolized by cytochrome P450 3A4, have revealed substantial and clinically …”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.).
What does the alprazolam label say about nefazodone?
Alprazolam label, drug interactionsExamples; Nefazodone, fluvoxamine, cimetidine, erythromycin
Alprazolam label, warnings and precautionsDrugs demonstrated to be CYP3A inhibitors on the basis of clinical studies involving alprazolam: nefazodone, fluvoxamine, and cimetidine [see Drug Interaction (7.1), Clinical Pharmacology (12.3) ].
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the nefazodone label say about alprazolam?
Nefazodone label, drug interactionsTriazolam/Alprazolam – See CONTRAINDICATIONS and WARNINGS .
Nefazodone label, warningsInteraction with Triazolobenzodiazepines Interaction studies of nefazodone with two triazolobenzodiazepines, i.e., triazolam and alprazolam, metabolized by cytochrome P450 3A4, have revealed substantial and clinically important increases in plasma concentrations of these compounds when administered concomitantly with nefazodone.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Nefazodone | |
|---|---|---|
| Labeled for | Anxiety | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $1.17 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once