What the FDA labels say about taking them together
Alprazolam and ketorolac
Ketorolac's FDA label (Sprix) of December 5, 2024 names alprazolam in its drug interactions section; the alprazolam labels PlainMeds reads (2) do not name ketorolac.
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the ketorolac FDA label on DailyMed (effective August 31, 2023, Fresenius Kabi USA, LLC).
What does the alprazolam label say about ketorolac?
Alprazolam's label (effective January 18, 2023) and its 1 other brand-application label do not name ketorolac in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the ketorolac label say about alprazolam?
Sprix label (Zyla Life Sciences US LLC, December 5, 2024), drug interactionsClinical Impact: Hallucinations have been reported when ketorolac was used in patients taking psychoactive drugs (…). Intervention: During concomitant use of SPRIX and psychoactive drugs, monitor patients for hallucinations.
Source: FDA drug label (Sprix, NDA022382), Zyla Life Sciences US LLC, effective December 5, 2024 (SPL set 97005a1c-167e-4676-bae7-e49b38c36f9e), via openFDA
Source: FDA drug label (Ketorolac Tromethamine), Fresenius Kabi USA, LLC, effective August 31, 2023 (SPL set 3d88cbe6-5230-47aa-80af-0c41283d1f00), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Ketorolac | |
|---|---|---|
| Labeled for | Anxiety | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $1.02 per mL 30 mg/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once