What the FDA labels say about taking them together
Alprazolam and fosaprepitant
Fosaprepitant's FDA label of July 29, 2026 names alprazolam in its drug interactions section; the alprazolam labels PlainMeds reads (2) do not name fosaprepitant. The fosaprepitant label: “Clinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions.”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the fosaprepitant FDA label on DailyMed (effective July 29, 2026, AVYXA Pharma, LLC).
What does the alprazolam label say about fosaprepitant?
Alprazolam's label (effective January 18, 2023) and its 1 other brand-application label do not name fosaprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the fosaprepitant label say about alprazolam?
Fosaprepitant label, drug interactionsClinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see ].
Source: FDA drug label (Focinvez, NDA216686), Steriscience Specialties Private Limited, effective March 30, 2026 (SPL set 18a60093-cec8-1b8c-e063-6394a90a8902), via openFDA
Source: FDA drug label (NAVITRUX), AVYXA Pharma, LLC, effective July 29, 2026 (SPL set a41b7c3a-1376-43a7-b5b9-6ba2eba1e169), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Fosaprepitant | |
|---|---|---|
| Labeled for | Anxiety | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once