What the FDA labels say about taking them together
Alprazolam and fosamprenavir
Fosamprenavir's FDA label of September 15, 2023 names alprazolam in its drug interactions section; the alprazolam labels PlainMeds reads (2) do not name fosamprenavir. The fosamprenavir label: “Clinical significance is unknown. A decrease in benzodiazepine dose may be needed.”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).
What does the alprazolam label say about fosamprenavir?
Alprazolam's label (effective January 18, 2023) and its 1 other brand-application label do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the fosamprenavir label say about alprazolam?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Benzodiazepines: Alprazolam, clorazepate, diazepam, flurazepam; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Benzodiazepines; Clinical Comment: Clinical significance is unknown. A decrease in benzodiazepine dose may be needed.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Fosamprenavir | |
|---|---|---|
| Labeled for | Anxiety | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once