Alosetron and Cimetidine Interaction
Drug interaction information between Alosetron and Cimetidine.
Alosetron and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alosetron and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine may block the body from breaking down alosetron, which could lead to higher drug levels in your system.
FDA Label Information
Concomitant administration of alosetron and moderate CYP1A2 inhibitors, including quinolone antibiotics and cimetidine, has not been evaluated, but should be avoided unless clinically necessary because of similar potential drug interactions.
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Voriconazole moderate
- Estradiol minor
- Hydralazine minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Alosetron + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Alosetron's 12. In the minor band specifically: Alosetron has 9 (also Estradiol, Hydralazine, Ketoconazole, Theophylline); Cimetidine has 63 (also Albendazole, Alogliptin, Alprazolam, Amiodarone).
What mechanism field is on file for Alosetron and Cimetidine?
Cimetidine may block the body from breaking down alosetron, which could lead to higher drug levels in your system.
Cimetidine carries more major-labeled pairs than Alosetron
SPL source-record counts only. This page's band is minor · classes on file: Alosetron (5-HT3 Antagonist (IBS-D)); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Alosetron's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Alosetron
- Estradiol
- Hydralazine
- Ketoconazole
- Theophylline
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alprazolam
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.