What the FDA labels say about taking them together
Almotriptan and ketoconazole
Almotriptan's FDA label of December 31, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name almotriptan. The almotriptan label: “… life-threatening serotonin syndrome reported during combined use with triptans Ketoconazole: use single dose of almotriptan tablets 6.25 mg; maximum almotriptan tablets daily dose 12.5 mg”
Check it at the source: the almotriptan FDA label on DailyMed (effective December 31, 2025, Ajanta Pharma USA Inc.); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the almotriptan label say about ketoconazole?
Almotriptan label, drug interactionsDRUG INTERACTIONS Do not use almotriptan tablets and ergotamine-containing or ergot-type medications within 24 hours of each other ( 4.5 , 7.1 ) Do not use almotriptan tablets and other 5-HT 1 agonists (e.g., triptans) within 24 hours of each other ( 4.6 , 7.2 ) SSRI or SNRI: life-threatening serotonin syndrome reported during combined use with triptans ( 5.5 , 7.3 ) Ketoconazole: use single dose of almotriptan tablets 6.25 mg; maximum almotriptan tablets daily dose 12.5 mg
Source: FDA drug label (almotriptan), Ajanta Pharma USA Inc., effective December 31, 2025 (SPL set 6fa380c4-c885-4743-85bf-88819ae68645), via openFDA; the full label on DailyMed
What does the ketoconazole label say about almotriptan?
Ketoconazole's label (effective January 28, 2026) does not name almotriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Almotriptan | Ketoconazole | |
|---|---|---|
| Labeled for | Migraine, Pain | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $16.86 per tablet 12.5 mg tablet | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once