What the FDA labels say about taking them together
Almotriptan and fluoxetine
Almotriptan's FDA label of December 31, 2025 names fluoxetine in its warnings and precautions section; the fluoxetine label PlainMeds reads does not name almotriptan. The almotriptan label: “If concomitant treatment with almotriptan tablets and an SSRI or SNRI is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.”
Check it at the source: the almotriptan FDA label on DailyMed (effective December 31, 2025, Ajanta Pharma USA Inc.); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the almotriptan label say about fluoxetine?
Almotriptan label, warnings and precautionsIf concomitant treatment with almotriptan tablets and an SSRI (e.g., fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram) or SNRI (e.g., venlafaxine, duloxetine) is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.
Source: FDA drug label (almotriptan), Ajanta Pharma USA Inc., effective December 31, 2025 (SPL set 6fa380c4-c885-4743-85bf-88819ae68645), via openFDA; the full label on DailyMed
What does the fluoxetine label say about almotriptan?
Fluoxetine's label (effective January 8, 2026) does not name almotriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Almotriptan | Fluoxetine | |
|---|---|---|
| Labeled for | Migraine, Pain | Depression, Anxiety, Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $16.86 per tablet 12.5 mg tablet | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once