What the FDA labels say about taking them together
Almotriptan and ergotamine
Almotriptan's FDA label of December 31, 2025 names ergotamine in its contraindications section; the ergotamine label PlainMeds reads does not name almotriptan. The almotriptan label: “Do not use almotriptan tablets and ergotamine-containing or ergot-derived medications like dihydroergotamine, ergotamine tartrate, or methysergide within 24 hours of each other.”
Check it at the source: the almotriptan FDA label on DailyMed (effective December 31, 2025, Ajanta Pharma USA Inc.); the ergotamine FDA label on DailyMed (effective February 25, 2025, Pangea Pharmaceuticals LLC).
What does the almotriptan label say about ergotamine?
Almotriptan label, contraindicationsDo not use almotriptan tablets and ergotamine-containing or ergot-derived medications like dihydroergotamine, ergotamine tartrate, or methysergide within 24 hours of each other [see Drug Interactions ( 7.1 )].
Almotriptan label, drug interactionsBecause, in theory, vasospastic effects may be additive, ergotamine-containing or ergot-type medications (like dihydroergotamine, ergotamine tartrate, or methysergide) and almotriptan tablets should not be used within 24 hours of each other [see Contraindications ( 4.5 )].
Almotriptan label, warnings and precautionsOveruse of acute migraine drugs (e.g., ergotamine, triptans, opioids, or combination of these drugs for 10 or more days per month) may lead to exacerbation of headache (medication overuse headache).
Source: FDA drug label (almotriptan), Ajanta Pharma USA Inc., effective December 31, 2025 (SPL set 6fa380c4-c885-4743-85bf-88819ae68645), via openFDA; the full label on DailyMed
What does the ergotamine label say about almotriptan?
Ergotamine's label (effective February 25, 2025) does not name almotriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ergomar Sublingual), Pangea Pharmaceuticals LLC, effective February 25, 2025 (SPL set a9582fdb-7ddd-4f69-aa7a-66247cdb8c92), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Almotriptan | Ergotamine | |
|---|---|---|
| Labeled for | Migraine, Pain | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $16.86 per tablet 12.5 mg tablet | $43.46 per tablet 2 mg tablet sublingual |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once