What the FDA labels say about taking them together
Almotriptan and dihydroergotamine
Almotriptan's FDA label of December 31, 2025 names dihydroergotamine in its contraindications section; the dihydroergotamine labels PlainMeds reads (4) do not name almotriptan. The almotriptan label: “Do not use almotriptan tablets and ergotamine-containing or ergot-derived medications like dihydroergotamine, ergotamine tartrate, or methysergide within 24 hours of each other.”
Check it at the source: the almotriptan FDA label on DailyMed (effective December 31, 2025, Ajanta Pharma USA Inc.); the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals).
What does the almotriptan label say about dihydroergotamine?
Almotriptan label, contraindicationsDo not use almotriptan tablets and ergotamine-containing or ergot-derived medications like dihydroergotamine, ergotamine tartrate, or methysergide within 24 hours of each other [see Drug Interactions ( 7.1 )].
Almotriptan label, drug interactionsBecause, in theory, vasospastic effects may be additive, ergotamine-containing or ergot-type medications (like dihydroergotamine, ergotamine tartrate, or methysergide) and almotriptan tablets should not be used within 24 hours of each other [see Contraindications ( 4.5 )].
Source: FDA drug label (almotriptan), Ajanta Pharma USA Inc., effective December 31, 2025 (SPL set 6fa380c4-c885-4743-85bf-88819ae68645), via openFDA; the full label on DailyMed
What does the dihydroergotamine label say about almotriptan?
Dihydroergotamine's label (effective March 6, 2025) and its 3 other brand-application labels do not name almotriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Almotriptan | Dihydroergotamine | |
|---|---|---|
| Labeled for | Migraine, Pain | Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $16.86 per tablet 12.5 mg tablet | $29.44 per mL 4 mg/mL nasal spray |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once