What the FDA labels say about taking them together
Allopurinol and doxorubicin
Allopurinol's FDA label of May 21, 2026 names doxorubicin in its drug interactions section, and doxorubicin's label names allopurinol too. The allopurinol label: “… not increase the marrow toxicity of patients treated with cyclophosphamide, doxorubicin, bleomycin, procarbazine and/or mechlorethamine.”
Check it at the source: the allopurinol FDA label on DailyMed (effective May 21, 2026, Rising Pharma Holdings, Inc.); the doxorubicin FDA label on DailyMed (effective May 5, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the allopurinol label say about doxorubicin?
Allopurinol label, drug interactionsClinical Impact; Concomitant use of allopurinol with cyclophosphamide and other cytotoxic agents (doxorubicin, bleomycin, procarbazine, mechloroethamine) increases bone marrow suppression among patients with neoplastic disease, except leukemia.
Allopurinol label (Proficient Rx LP, February 1, 2023), drug interactionsHowever, in a well-controlled study of patients with lymphoma on combination therapy, allopurinol did not increase the marrow toxicity of patients treated with cyclophosphamide, doxorubicin, bleomycin, procarbazine and/or mechlorethamine.
Source: FDA drug label (Allopurinol, NDA018877), Proficient Rx LP, effective February 1, 2023 (SPL set 0ca4baed-c5d8-4de4-ac17-6e5d1df15c03), via openFDA
Source: FDA drug label (Allopurinol), Rising Pharma Holdings, Inc., effective May 21, 2026 (SPL set 30ad5ba2-1cef-4933-b104-0597f6a2aaa2), via openFDA; the full label on DailyMed
What does the doxorubicin label say about allopurinol?
Doxorubicin label, warnings and precautionsHydration, urine alkalinization, and prophylaxis with allopurinol to prevent hyperuricemia may minimize potential complications of tumor lysis syndrome.
Source: FDA drug label (Doxorubicin Hydrochloride), Pfizer Laboratories Div Pfizer Inc, effective May 5, 2026 (SPL set 1fd148fb-0fbc-4b6f-b790-23546fb46a71), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Allopurinol | Doxorubicin | |
|---|---|---|
| Labeled for | Gout | Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0315 per tablet 100 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once