What the FDA labels say about taking them together
Allopurinol and cyclosporine
Allopurinol's FDA label of May 21, 2026 names cyclosporine in its drug interactions section, and cyclosporine's label names allopurinol too. The allopurinol label: “Monitoring of cyclosporine levels and possible adjustment of cyclosporine dosage should be considered when these drugs are co-administered.”
Check it at the source: the allopurinol FDA label on DailyMed (effective May 21, 2026, Rising Pharma Holdings, Inc.); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the allopurinol label say about cyclosporine?
Allopurinol label, drug interactionsCyclosporine Clinical Impact Concomitant use of allopurinol increases cyclosporine concentrations, which may increase the risk of adverse reactions. Intervention Increase frequency of monitoring cyclosporine concentrations as reflected in its prescribing information and modify the dosage of cyclosporine as appropriate when used concomitantly with allopurinol tablets.
Allopurinol label (Proficient Rx LP, February 1, 2023), drug interactionsMonitoring of cyclosporine levels and possible adjustment of cyclosporine dosage should be considered when these drugs are co-administered.
Source: FDA drug label (Aloprim, NDA020298), Mylan Institutional LLC, effective February 18, 2022 (SPL set 10cc918f-aa44-415b-932d-2404695ac449), via openFDA
Source: FDA drug label (Allopurinol, NDA018877), Proficient Rx LP, effective February 1, 2023 (SPL set 0ca4baed-c5d8-4de4-ac17-6e5d1df15c03), via openFDA
Source: FDA drug label (Allopurinol), Rising Pharma Holdings, Inc., effective May 21, 2026 (SPL set 30ad5ba2-1cef-4933-b104-0597f6a2aaa2), via openFDA; the full label on DailyMed
What does the cyclosporine label say about allopurinol?
Cyclosporine label, drug interactionsdiltiazem; fluconazole; azithromycin; methylprednisolone; Allopurinol
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Allopurinol | Cyclosporine | |
|---|---|---|
| Labeled for | Gout | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0315 per tablet 100 mg tablet | $1.04 per unit 0.05% eye emulsion |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once