Allopurinol and Cyclosporine Interaction
Drug interaction information between Allopurinol and Cyclosporine.
Allopurinol and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Allopurinol and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Allopurinol slows down how your body gets rid of cyclosporine, leading to higher levels of the drug in your system.
FDA Label Information
Cyclosporine Clinical Impact Concomitant use of allopurinol increases cyclosporine concentrations, which may increase the risk of adverse reactions. Intervention Increase frequency of monitoring cyclosporine concentrations as reflected in its prescribing information and modify the dosage of cyclosporine as appropriate when used concomitantly with allopurinol tablets.
Allopurinol Also Interacts With
- Pegloticase major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Warfarin minor
- Theophylline minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Allopurinol + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Allopurinol's 10. In the moderate band specifically: Allopurinol has 3 (also Amoxicillin, Amoxicillin/Clavulanate); Cyclosporine has 24 (also Aliskiren, Amiloride, Amlodipine/Valsartan, Atorvastatin).
What mechanism field is on file for Allopurinol and Cyclosporine?
Allopurinol slows down how your body gets rid of cyclosporine, leading to higher levels of the drug in your system.
Cyclosporine carries more major-labeled pairs than Allopurinol
SPL source-record counts only. This page's band is moderate · classes on file: Allopurinol (Xanthine Oxidase Inhibitor); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Allopurinol's 1. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 6 minor · 10 total
- Other moderate peers for Allopurinol
- Amoxicillin
- Amoxicillin/Clavulanate
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Amiloride
- Amlodipine/Valsartan
- Atorvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.