What the FDA labels say about taking them together
Allopurinol and capecitabine
Allopurinol's FDA label of May 21, 2026 names capecitabine in its drug interactions section, and capecitabine's label names allopurinol too. The allopurinol label: “Capecitabine: Avoid the concomitant use of allopurinol.”
Check it at the source: the allopurinol FDA label on DailyMed (effective May 21, 2026, Rising Pharma Holdings, Inc.); the capecitabine FDA label on DailyMed (effective February 5, 2026, H2-Pharma, LLC).
What does the allopurinol label say about capecitabine?
Allopurinol label, drug interactionsClinical Impact; Concomitant use with allopurinol may decrease concentration of capecitabine’s active metabolites, which may decrease capecitabine efficacy.
Aloprim label (Mylan Institutional LLC, February 18, 2022), drug interactionsCapecitabine: Avoid the concomitant use of allopurinol ( 7.2 ).
Source: FDA drug label (Aloprim, NDA020298), Mylan Institutional LLC, effective February 18, 2022 (SPL set 10cc918f-aa44-415b-932d-2404695ac449), via openFDA
Source: FDA drug label (Allopurinol), Rising Pharma Holdings, Inc., effective May 21, 2026 (SPL set 30ad5ba2-1cef-4933-b104-0597f6a2aaa2), via openFDA; the full label on DailyMed
What does the capecitabine label say about allopurinol?
Capecitabine label, drug interactionsDRUG INTERACTIONS Allopurinol: Avoid concomitant use of allopurinol with XELODA.
Source: FDA drug label (XELODA), NDA020896 (Cheplapharm), as published by H2-Pharma, LLC, effective February 5, 2026 (SPL set e702d84d-7162-4751-bf37-d724cc7e45a5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Allopurinol | Capecitabine | |
|---|---|---|
| Labeled for | Gout | Colorectal cancer, Breast cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0315 per tablet 100 mg tablet | $0.456 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once