What the FDA labels say about taking them together
Aliskiren and sparsentan
Sparsentan's FDA label of April 9, 2026 names aliskiren in its contraindications section; aliskiren's label does not name sparsentan itself but warns about its class (ARBs (angiotensin II receptor blockers)). The sparsentan label: “Do not co-administer FILSPARI with ARBs, ERAs, or aliskiren.”
Check it at the source: the aliskiren FDA label on DailyMed (effective March 7, 2024, LXO US Inc.); the sparsentan FDA label on DailyMed (effective April 9, 2026, Travere Therapeutics, Inc.).
What does the aliskiren label say about sparsentan?
Aliskiren's label does not name sparsentan itself; it warns about its class (ARBs (angiotensin II receptor blockers)):
Aliskiren label, warnings and precautionsRenal Impairment/Hyperkalemia/Hypotension when Tekturna is Given in Combination with ARBs or ACEIs Tekturna is contraindicated in patients with diabetes who are receiving ARBs or ACEIs because of the increased risk of renal impairment, hyperkalemia, and hypotension.
Aliskiren label, contraindicationsCONTRAINDICATIONS Do not use Tekturna with ARBs or ACEIs in patients with diabetes [see Warnings and Precautions ( 5.2 ) and Clinical Studies ( 14.3 )].
Source: FDA drug label (Tekturna), NDA021985 (Lxo Ireland), as published by LXO US Inc., effective March 7, 2024 (SPL set 3dd61fa5-1620-4ebf-bbdb-ede29b92fce2), via openFDA; the full label on DailyMed
What does the sparsentan label say about aliskiren?
Sparsentan label, contraindicationsDo not co-administer FILSPARI with ARBs, ERAs, or aliskiren [see Dosage and Administration ( 2.1 ), Drug Interactions ( 7.1 )].
Source: FDA drug label (FILSPARI), Travere Therapeutics, Inc., effective April 9, 2026 (SPL set d7354af1-f304-f4d9-e053-2995a90ab219), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aliskiren | Sparsentan | |
|---|---|---|
| Labeled for | High blood pressure | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $3.94 per tablet 150 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once