What the FDA labels say about taking them together
Aliskiren and ramipril
Ramipril's FDA label of August 24, 2026 names aliskiren in its contraindications section; aliskiren's label does not name ramipril itself but warns about its class (ACE inhibitors). The ramipril label: “Do not co-administer aliskiren with ramipril in patients with diabetes.”
Check it at the source: the aliskiren FDA label on DailyMed (effective March 7, 2024, LXO US Inc.); the ramipril FDA label on DailyMed (effective August 24, 2026, Lupin Pharmaceuticals, Inc.).
What does the aliskiren label say about ramipril?
Aliskiren's label does not name ramipril itself; it warns about its class (ACE inhibitors):
Aliskiren label, warnings and precautionsIn general, avoid combined use of Tekturna with ACE inhibitors or ARBs, particularly in patients with creatinine clearance (CrCl) less than 60 mL/min [see Contraindications ( 4 ), Drug Interactions ( 7 ) and Clinical Studies ( 14.3 )].
Aliskiren label, drug interactionsIn general, avoid combined use of aliskiren with ACE inhibitors or ARBs, particularly in patients with CrCl less than 60 mL/min.
Source: FDA drug label (Tekturna), NDA021985 (Lxo Ireland), as published by LXO US Inc., effective March 7, 2024 (SPL set 3dd61fa5-1620-4ebf-bbdb-ede29b92fce2), via openFDA; the full label on DailyMed
What does the ramipril label say about aliskiren?
Ramipril label, contraindicationsDo not co-administer aliskiren with ramipril in patients with diabetes ( 4 ).
Ramipril label, warnings and precautionsBlockade of the Renin-Angiotensin System Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy.
Source: FDA drug label (Ramipril), Lupin Pharmaceuticals, Inc., effective August 24, 2026 (SPL set a8cdec12-81d1-4ef4-82c0-d05d93c37a07), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aliskiren | Ramipril | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, Heart attack and coronary artery disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $3.94 per tablet 150 mg tablet | $0.0707 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once