What the FDA labels say about taking them together
Aliskiren and quinapril
Quinapril's FDA label of December 14, 2023 names aliskiren in its contraindications section; aliskiren's label does not name quinapril itself but warns about its class (ACE inhibitors). The quinapril label: “Do not co-administer quinapril with aliskiren in patients with diabetes.”
Check it at the source: the aliskiren FDA label on DailyMed (effective March 7, 2024, LXO US Inc.); the quinapril FDA label on DailyMed (effective December 14, 2023, Lupin Pharmaceuticals, Inc.).
What does the aliskiren label say about quinapril?
Aliskiren's label does not name quinapril itself; it warns about its class (ACE inhibitors):
Aliskiren label, warnings and precautionsIn general, avoid combined use of Tekturna with ACE inhibitors or ARBs, particularly in patients with creatinine clearance (CrCl) less than 60 mL/min [see Contraindications ( 4 ), Drug Interactions ( 7 ) and Clinical Studies ( 14.3 )].
Aliskiren label, drug interactionsIn general, avoid combined use of aliskiren with ACE inhibitors or ARBs, particularly in patients with CrCl less than 60 mL/min.
Source: FDA drug label (Tekturna), NDA021985 (Lxo Ireland), as published by LXO US Inc., effective March 7, 2024 (SPL set 3dd61fa5-1620-4ebf-bbdb-ede29b92fce2), via openFDA; the full label on DailyMed
What does the quinapril label say about aliskiren?
Quinapril label, contraindicationsDo not co-administer quinapril with aliskiren in patients with diabetes.
Source: FDA drug label (Quinapril), Lupin Pharmaceuticals, Inc., effective December 14, 2023 (SPL set 8ded0773-3aec-4e89-9836-d22a5a84abf0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aliskiren | Quinapril | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, Heart failure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $3.94 per tablet 150 mg tablet | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once