What the FDA labels say about taking them together

Alglucosidase alfa and epinephrine

Alglucosidase alfa's FDA label of January 10, 2025 names epinephrine in its boxed warning section; the epinephrine labels PlainMeds reads (4) do not name alglucosidase alfa.

Check it at the source: the alglucosidase alfa FDA label on DailyMed (effective January 10, 2025, Genzyme Corporation); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).

What does the alglucosidase alfa label say about epinephrine?

Alglucosidase alfa label, boxed warning
If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue LUMIZYME and immediately initiate appropriate medical treatment, including use of epinephrine. ( 5.1 ) Immune-Mediated Reactions Immune-mediated reactions presenting as proteinuria, nephrotic syndrome, and necrotizing skin lesions have occurred in some patients following LUMIZYME treatment.

Alglucosidase alfa label, warnings and precautions
In some cases of anaphylaxis, epinephrine was administered.

Source: FDA drug label (Lumizyme), Genzyme Corporation, effective January 10, 2025 (SPL set d6bfbc45-2d34-439e-8aad-59ee2d53d4df), via openFDA; the full label on DailyMed

What does the epinephrine label say about alglucosidase alfa?

Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name alglucosidase alfa in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Alglucosidase alfa generic labelers

16Epinephrine generic labelers

	Alglucosidase alfa	Epinephrine
Labeled for	n/a	Asthma
Boxed warning	Yes	No
Pharmacy cost (NADAC)	n/a	$123.51 per unit 0.15 mg auto-injct
Shortage now	No current entry	A presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Alglucosidase alfa: the full record
Epinephrine: the full record
Check more medicines together: up to five at once