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What the FDA labels say about taking them together

Alfuzosin and fosamprenavir

Fosamprenavir's FDA label of September 15, 2023 names alfuzosin in its contraindications section; the alfuzosin label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Coadministration is contraindicated due to potential hypotension.”

Check it at the source: the alfuzosin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).

What does the alfuzosin label say about fosamprenavir?

Alfuzosin's label (effective December 5, 2024) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Uroxatral), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set 9fc7f119-f36b-44cf-945d-940160f3afe3), via openFDA; the full label on DailyMed

What does the fosamprenavir label say about alfuzosin?

Fosamprenavir label, contraindications

Alfuzosin o Antiarrhythmics: Flecainide (with ritonavir ), propafenone (with ritonavir ) o Antimycobacterial:

Fosamprenavir label, drug interactions

Concomitant Drug Class/Drug Name: Alpha 1-adrenoreceptor antagonist: Alfuzosin; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Alfuzosin; Clinical Comment: Coadministration is contraindicated due to potential hypotension [see ].

Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

10Alfuzosin generic labelers
2Fosamprenavir generic labelers
AlfuzosinFosamprenavir
Labeled forEnlarged prostate (BPH)HIV
Boxed warningNoNo
Pharmacy cost (NADAC)$0.105 per tablet 10 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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