What the FDA labels say about taking them together
Alendronate/cholecalciferol and cimetidine
Alendronate/cholecalciferol's FDA label of February 3, 2026 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name alendronate/cholecalciferol. The alendronate/cholecalciferol label: “Drugs that May Increase the Catabolism of Cholecalciferol Anticonvulsants, cimetidine, and thiazides may increase the catabolism of vitamin D. Additional vitamin D supplementation should be considered.”
Check it at the source: the alendronate/cholecalciferol FDA label on DailyMed (effective February 3, 2026); the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).
What does the alendronate/cholecalciferol label say about cimetidine?
Alendronate/cholecalciferol label, drug interactionsDrugs that May Increase the Catabolism of Cholecalciferol Anticonvulsants, cimetidine, and thiazides may increase the catabolism of vitamin D. Additional vitamin D supplementation should be considered [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (FOSAMAX PLUS D), Organon LLC, effective February 3, 2026 (SPL set 10307e7e-9a84-4aa1-8c5c-4b209cffe4d1), via openFDA; the full label on DailyMed
What does the cimetidine label say about alendronate/cholecalciferol?
Cimetidine's label (effective July 15, 2026) does not name alendronate/cholecalciferol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alendronate/cholecalciferol | Cimetidine | |
|---|---|---|
| Labeled for | Osteoporosis | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $52.51 per unit 70 mg-5600 unit | $0.236 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once