What the FDA labels say about taking them together
Alendronate and romosozumab
Romosozumab's FDA label of July 16, 2026 names alendronate in its warnings and precautions section; the alendronate labels PlainMeds reads (2) do not name romosozumab.
Check it at the source: the alendronate FDA label on DailyMed (effective March 12, 2026, Organon LLC); the romosozumab FDA label on DailyMed (effective July 16, 2026).
What does the alendronate label say about romosozumab?
Alendronate's label (effective March 12, 2026) and its 1 other brand-application label do not name romosozumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (FOSAMAX), Organon LLC, effective March 12, 2026 (SPL set 14e931fd-2c5f-4d90-b7db-5980706f4a56), via openFDA; the full label on DailyMed
What does the romosozumab label say about alendronate?
Romosozumab label, warnings and precautionsEvents (MACE) In a randomized controlled trial in postmenopausal women, there was a higher rate of major adverse cardiac events (MACE), a composite endpoint of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke, in patients treated with EVENITY compared to those treated with alendronate [see Boxed Warning and Adverse Reactions (6.1) ].
Source: FDA drug label (Evenity), Amgen, Inc, effective July 16, 2026 (SPL set 471baba2-7154-4488-9891-0db2f46791e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alendronate | Romosozumab | |
|---|---|---|
| Labeled for | Osteoporosis | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.256 per tablet 70 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once