What the FDA labels say about taking them together
Alemtuzumab and ponesimod
Ponesimod's FDA label of December 4, 2025 names alemtuzumab in its drug interactions section; the alemtuzumab label PlainMeds reads does not name ponesimod. The ponesimod label: “Initiating treatment with PONVORY after treatment with alemtuzumab is not recommended.”
Check it at the source: the alemtuzumab FDA label on DailyMed (effective November 3, 2025, Genzyme Corporation); the ponesimod FDA label on DailyMed (effective December 4, 2025, Vanda Pharmaceuticals Inc.).
What does the alemtuzumab label say about ponesimod?
Alemtuzumab's label (effective November 3, 2025) does not name ponesimod in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LEMTRADA), Genzyme Corporation, effective November 3, 2025 (SPL set 6236b0bc-82e9-4447-9a78-f57d94770269), via openFDA; the full label on DailyMed
What does the ponesimod label say about alemtuzumab?
Ponesimod label, drug interactionsBecause of the characteristics and duration of alemtuzumab immune suppressive effects, initiating treatment with PONVORY after alemtuzumab is not recommended.
Ponesimod label, warnings and precautionsInitiating treatment with PONVORY after treatment with alemtuzumab is not recommended.
Source: FDA drug label (PONVORY), Vanda Pharmaceuticals Inc., effective December 4, 2025 (SPL set 0c025ba8-ba51-272e-e063-6294a90ad120), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alemtuzumab | Ponesimod | |
|---|---|---|
| Labeled for | Multiple sclerosis, Leukemia, lymphoma and myeloma | Multiple sclerosis |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once