What the FDA labels say about taking them together
Aflibercept and aflibercept-mrbb
Aflibercept-mrbb's FDA label of October 27, 2025 names aflibercept in its contraindications section; the aflibercept labels PlainMeds reads (4) do not name aflibercept-mrbb. The aflibercept-mrbb label: “Acute increases in intraocular pressure have been seen within 60 minutes of intravitreal injection, including with aflibercept products.”
Check it at the source: the aflibercept FDA label on DailyMed (effective April 6, 2026, Regeneron Pharmaceuticals, Inc); the aflibercept-mrbb FDA label on DailyMed (effective October 27, 2025, Valorum Biologics, LLC).
What does the aflibercept label say about aflibercept-mrbb?
Aflibercept's label (effective April 6, 2026) and its 3 other brand-application labels do not name aflibercept-mrbb in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (EYLEA HD), Regeneron Pharmaceuticals, Inc, effective April 6, 2026 (SPL set 86d8848b-111b-4da9-8957-7cccef1b8f66), via openFDA; the full label on DailyMed
What does the aflibercept-mrbb label say about aflibercept?
Aflibercept-mrbb label, contraindicationsHypersensitivity AHZANTIVE is contraindicated in patients with known hypersensitivity to aflibercept or any of the excipients in AHZANTIVE.
Aflibercept-mrbb label, warnings and precautionsAcute increases in intraocular pressure have been seen within 60 minutes of intravitreal injection, including with aflibercept products [see Adverse Reactions (6.1)].
Source: FDA drug label (AHZANTIVE), BLA761378 (Formycon Ag), as published by Valorum Biologics, LLC, effective October 27, 2025 (SPL set 289e4b90-f741-c0f6-e063-6394a90a2068), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aflibercept | Aflibercept-mrbb | |
|---|---|---|
| Labeled for | Colorectal cancer | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once