What the FDA labels say about taking them together
Afatinib and loperamide
Afatinib's FDA label of November 13, 2025 names loperamide in its warnings and precautions section; the loperamide label PlainMeds reads does not name afatinib.
Check it at the source: the afatinib FDA label on DailyMed (effective November 13, 2025, Boehringer Ingelheim Pharmaceuticals, Inc.); the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited).
What does the afatinib label say about loperamide?
Afatinib label, warnings and precautionsWithhold GILOTRIF for severe and prolonged diarrhea not responsive to anti-diarrheal agents. ( 2.3 , 5.1 ) Bullous and exfoliative skin disorders:
Source: FDA drug label (Gilotrif), Boehringer Ingelheim Pharmaceuticals, Inc., effective November 13, 2025 (SPL set fd638e5e-8032-e7ca-0179-95e96ab5d387), via openFDA; the full label on DailyMed
What does the loperamide label say about afatinib?
Loperamide's label (effective June 3, 2026) does not name afatinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Afatinib | Loperamide | |
|---|---|---|
| Labeled for | Lung cancer | Diarrhea |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0549 per capsule 2 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once