What the FDA labels say about taking them together
Adefovir dipivoxil and tenofovir disoproxil
Adefovir dipivoxil's FDA label of July 22, 2025 names tenofovir disoproxil in its drug interactions section, and tenofovir disoproxil's label names adefovir dipivoxil too.
Check it at the source: the adefovir dipivoxil FDA label on DailyMed (effective July 22, 2025, Apotex Corp.); the tenofovir disoproxil FDA label on DailyMed (effective June 7, 2024, Aurobindo Pharma Limited).
What does the adefovir dipivoxil label say about tenofovir disoproxil?
Adefovir dipivoxil label, drug interactionsAdefovir dipivoxil should not be administered in combination with VIREAD [ See Warnings and Precautions (5.5)].
Adefovir dipivoxil label, warnings and precautionsAdefovir dipivoxil should not be used concurrently with products containing tenofovir disoproxil fumarate or tenofovir alafenamide.
Source: FDA drug label (Adefovir dipivoxil), Apotex Corp., effective July 22, 2025 (SPL set 08e07fae-3191-b6a3-c894-d3a8cc53923f), via openFDA; the full label on DailyMed
What does the tenofovir disoproxil label say about adefovir dipivoxil?
Tenofovir disoproxil label, drug interactionsIn the treatment of chronic hepatitis B, tenofovir disoproxil fumarate should not be administered in combination with HEPSERA (adefovir dipivoxil).
Source: FDA drug label (Viread, NDA021356), Gilead Sciences, Inc., effective February 18, 2025 (SPL set 33fd6418-fbdc-42ca-a50d-ce2a476a5418), via openFDA
Source: FDA drug label (Tenofovir Disoproxil Fumarate), Aurobindo Pharma Limited, effective June 7, 2024 (SPL set a75c6be8-3719-4bb3-8a9e-06e5254d2a82), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Adefovir dipivoxil | Tenofovir disoproxil | |
|---|---|---|
| Labeled for | Hepatitis B | HIV, Hepatitis B |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $21.73 per tablet 10 mg tablet | $0.294 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once