What the FDA labels say about taking them together
Adefovir dipivoxil and lamivudine
Adefovir dipivoxil's FDA label of July 22, 2025 names lamivudine in its warnings and precautions section; the lamivudine labels PlainMeds reads (2) do not name adefovir dipivoxil. The adefovir dipivoxil label: “In order to reduce the risk of resistance in patients with lamivudine resistant HBV, adefovir dipivoxil should be used in combination with lamivudine and not as adefovir dipivoxil monotherapy.”
Check it at the source: the adefovir dipivoxil FDA label on DailyMed (effective July 22, 2025, Apotex Corp.); the lamivudine FDA label on DailyMed (effective January 5, 2026, Strides Pharma Science Limited).
What does the adefovir dipivoxil label say about lamivudine?
Adefovir dipivoxil label, warnings and precautionsIn order to reduce the risk of resistance in patients with lamivudine resistant HBV, adefovir dipivoxil should be used in combination with lamivudine and not as adefovir dipivoxil monotherapy.
Source: FDA drug label (Adefovir dipivoxil), Apotex Corp., effective July 22, 2025 (SPL set 08e07fae-3191-b6a3-c894-d3a8cc53923f), via openFDA; the full label on DailyMed
What does the lamivudine label say about adefovir dipivoxil?
Lamivudine's label (effective January 5, 2026) and its 1 other brand-application label do not name adefovir dipivoxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lamivudine), Strides Pharma Science Limited, effective January 5, 2026 (SPL set ac824c7e-9c9f-487b-ad2f-d50eaef5cbda), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Adefovir dipivoxil | Lamivudine | |
|---|---|---|
| Labeled for | Hepatitis B | HIV, Hepatitis B |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $21.73 per tablet 10 mg tablet | $0.489 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once