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What the FDA labels say about taking them together

Adapalene/benzoyl peroxide/clindamycin and atropine

Adapalene/benzoyl peroxide/clindamycin's FDA label of April 24, 2025 names atropine in its warnings and precautions section; the atropine labels PlainMeds reads (4) do not name adapalene/benzoyl peroxide/clindamycin.

Check it at the source: the adapalene/benzoyl peroxide/clindamycin FDA label on DailyMed (effective April 24, 2025, Bausch Health US LLC); the atropine FDA label on DailyMed (effective May 18, 2026, Hospira, Inc.).

What does the adapalene/benzoyl peroxide/clindamycin label say about atropine?

Adapalene/benzoyl peroxide/clindamycin label, warnings and precautions

Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen severe colitis.

Source: FDA drug label (Cabtreo), Bausch Health US LLC, effective April 24, 2025 (SPL set 9468da0f-9978-4c58-8135-0274c3415084), via openFDA; the full label on DailyMed

What does the atropine label say about adapalene/benzoyl peroxide/clindamycin?

Atropine's label (effective May 18, 2026) and its 3 other brand-application labels do not name adapalene/benzoyl peroxide/clindamycin in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Atropine Sulfate), Hospira, Inc., effective May 18, 2026 (SPL set ad8916e7-206e-409e-2582-30d072845dd4), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Adapalene/benzoyl peroxide/clindamycin generic labelers
22Atropine generic labelers
Adapalene/benzoyl peroxide/clindamycinAtropine
Labeled forAcnen/a
Boxed warningNoNo
Pharmacy cost (NADAC)n/a$7.74 per mL 1% eye drops
Shortage nowNo current entryIn shortage

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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