What the FDA labels say about taking them together
Adagrasib and cetuximab
Adagrasib's FDA label of March 25, 2026 names cetuximab in its warnings and precautions section; the cetuximab label PlainMeds reads does not name adagrasib. The adagrasib label: “In patients who received KRAZATI in combination with cetuximab, serious gastrointestinal adverse reactions included gastrointestinal bleeding in 8.5% including 1.1% Grade 3 or 4, gastrointestinal obstruction in 5.3% …”
Check it at the source: the adagrasib FDA label on DailyMed (effective March 25, 2026, Mirati Therapeutics, Inc); the cetuximab FDA label on DailyMed (effective April 16, 2026, ImClone LLC).
What does the adagrasib label say about cetuximab?
Adagrasib label, warnings and precautionsIn patients who received KRAZATI in combination with cetuximab [see Adverse Reactions (6.1) ], serious gastrointestinal adverse reactions included gastrointestinal bleeding in 8.5% including 1.1% Grade 3 or 4, gastrointestinal obstruction in 5.3% including 5.3% Grade 3 or 4, colitis in 1.1% including 1.1% Grade 3 and ileus in 1.1%.
Source: FDA drug label (KRAZATI), NDA216340 (Bristol), as published by Mirati Therapeutics, Inc, effective March 25, 2026 (SPL set 0b8bf078-34c2-4f45-9012-38a8ac082b01), via openFDA; the full label on DailyMed
What does the cetuximab label say about adagrasib?
Cetuximab's label (effective April 16, 2026) does not name adagrasib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ERBITUX), ImClone LLC, effective April 16, 2026 (SPL set 8bc6397e-4bd8-4d37-a007-a327e4da34d9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Adagrasib | Cetuximab | |
|---|---|---|
| Labeled for | Lung cancer, Colorectal cancer | Colorectal cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once