What the FDA labels say about taking them together
Acitretin and methotrexate
Acitretin's FDA label of August 5, 2026 names methotrexate in its contraindications section; the methotrexate labels PlainMeds reads (4) do not name acitretin. The acitretin label: “An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate.”
Check it at the source: the acitretin FDA label on DailyMed (effective August 5, 2026, Sigmapharm Laboratories, LLC); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the acitretin label say about methotrexate?
Acitretin label, contraindicationsAn increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate.
Source: FDA drug label (ACITRETIN), Sigmapharm Laboratories, LLC, effective August 5, 2026 (SPL set a6546625-acb8-460e-b34e-f795bfb3680a), via openFDA; the full label on DailyMed
What does the methotrexate label say about acitretin?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name acitretin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acitretin | Methotrexate | |
|---|---|---|
| Labeled for | Psoriasis | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2.59 per capsule 10 mg capsule | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once