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What the FDA labels say about taking them together

Acitretin and glyburide

Acitretin's FDA label of August 5, 2026 names glyburide in its drug interactions section; the glyburide label PlainMeds reads does not name acitretin.

Check it at the source: the acitretin FDA label on DailyMed (effective August 5, 2026, Sigmapharm Laboratories, LLC); the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc).

What does the acitretin label say about glyburide?

Acitretin label, drug interactions

In a trial of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose-lowering effect of glyburide (a sulfonylurea similar to chlorpropamide) in 3 of the 7 subjects.

Source: FDA drug label (ACITRETIN), Sigmapharm Laboratories, LLC, effective August 5, 2026 (SPL set a6546625-acb8-460e-b34e-f795bfb3680a), via openFDA; the full label on DailyMed

What does the glyburide label say about acitretin?

Glyburide's label (effective July 1, 2021) does not name acitretin in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

8Acitretin generic labelers
16Glyburide generic labelers
AcitretinGlyburide
Labeled forPsoriasisType 2 diabetes
Boxed warningYesNo
Pharmacy cost (NADAC)$2.59 per capsule 10 mg capsule$0.0643 per tablet 5 mg tablet
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?