What the FDA labels say about taking them together
Acetazolamide and lithium
Lithium's FDA label of December 23, 2025 names acetazolamide in its drug interactions section; the acetazolamide label PlainMeds reads does not name lithium. The lithium label: “Concomitant use may increase serum lithium concentrations due to reduced renal clearance.”
Check it at the source: the acetazolamide FDA label on DailyMed (effective August 19, 2026, Strides Pharma Science Limited); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the acetazolamide label say about lithium?
Acetazolamide's label (effective August 19, 2026) does not name lithium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Acetazolamide), Strides Pharma Science Limited, effective August 19, 2026 (SPL set 4813b9dd-5f58-44bb-ad64-cdb331828080), via openFDA; the full label on DailyMed
What does the lithium label say about acetazolamide?
Lithium label, drug interactionsClinical Impact: Concomitant use may increase serum lithium concentrations due to reduced renal clearance. Intervention: More frequent monitoring of serum lithium concentration. Reduce lithium dosage based on serum lithium concentration and clinical response [see Dosage and Administration ( 2.3 )]. Acetazolamide, Urea, Xanthine Preparations, Alkalinizing Agents
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetazolamide | Lithium | |
|---|---|---|
| Labeled for | n/a | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.134 per tablet 250 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once