What the FDA labels say about taking them together
Acetazolamide and aspirin
Acetazolamide's FDA label of August 19, 2026 names aspirin in its warnings section; the aspirin label PlainMeds reads does not name acetazolamide. The acetazolamide label: “Caution is advised for patients receiving concomitant high-dose aspirin and acetazolamide, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported.”
Check it at the source: the acetazolamide FDA label on DailyMed (effective August 19, 2026, Strides Pharma Science Limited); the aspirin FDA label on DailyMed (effective September 9, 2025).
What does the acetazolamide label say about aspirin?
Acetazolamide label, warningsCaution is advised for patients receiving concomitant high-dose aspirin and acetazolamide, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported.
Source: FDA drug label (Acetazolamide), Strides Pharma Science Limited, effective August 19, 2026 (SPL set 4813b9dd-5f58-44bb-ad64-cdb331828080), via openFDA; the full label on DailyMed
What does the aspirin label say about acetazolamide?
Aspirin's label (effective September 9, 2025) does not name acetazolamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetazolamide | Aspirin | |
|---|---|---|
| Labeled for | n/a | Pain, Cough and cold, Fever |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.134 per tablet 250 mg tablet | $0.0142 per tablet 81 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once