What the FDA labels say about taking them together
Acetazolamide and amphetamine
Amphetamine's FDA label of August 20, 2026 names acetazolamide in its drug interactions section; the acetazolamide label PlainMeds reads does not name amphetamine. The amphetamine label: “Urinary alkalinizing agents increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion.”
Check it at the source: the acetazolamide FDA label on DailyMed (effective August 19, 2026, Strides Pharma Science Limited); the amphetamine FDA label on DailyMed (effective August 20, 2026, Aurolife Pharma, LLC).
What does the acetazolamide label say about amphetamine?
Acetazolamide's label (effective August 19, 2026) does not name amphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Acetazolamide), Strides Pharma Science Limited, effective August 19, 2026 (SPL set 4813b9dd-5f58-44bb-ad64-cdb331828080), via openFDA; the full label on DailyMed
What does the amphetamine label say about acetazolamide?
Amphetamine label, drug interactionsUrinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion.
Source: FDA drug label (Amphetamine Sulfate), Aurolife Pharma, LLC, effective August 20, 2026 (SPL set 20735c2e-6304-425f-a4e4-584f6f90d6a0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetazolamide | Amphetamine | |
|---|---|---|
| Labeled for | n/a | ADHD |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.134 per tablet 250 mg tablet | $0.449 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once