What the FDA labels say about taking them together
Acetaminophen/caffeine/dihydrocodeine and disulfiram
Acetaminophen/caffeine/dihydrocodeine's FDA label of May 2, 2022 names disulfiram in its drug interactions section; the disulfiram label PlainMeds reads does not name acetaminophen/caffeine/dihydrocodeine. The acetaminophen/caffeine/dihydrocodeine label: “Co-administration of caffeine and disulfiram may lead to a substantial decrease in caffeine clearance.”
Check it at the source: the acetaminophen/caffeine/dihydrocodeine FDA label on DailyMed (effective May 2, 2022, Proficient Rx LP); the disulfiram FDA label on DailyMed (effective August 20, 2024, Sigmapharm Laboratories, LLC).
What does the acetaminophen/caffeine/dihydrocodeine label say about disulfiram?
Acetaminophen/caffeine/dihydrocodeine label, drug interactionsCo-administration of caffeine and disulfiram may lead to a substantial decrease in caffeine clearance.
Source: FDA drug label (Trezix), ANDA204785 (Key Therap), as published by Proficient Rx LP, effective May 2, 2022 (SPL set 45c3c2a1-6a89-471e-b6d4-5a4cd73b987a), via openFDA; the full label on DailyMed
What does the disulfiram label say about acetaminophen/caffeine/dihydrocodeine?
Disulfiram's label (effective August 20, 2024) does not name acetaminophen/caffeine/dihydrocodeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Disulfiram), Sigmapharm Laboratories, LLC, effective August 20, 2024 (SPL set 40f5497f-fe84-43b2-8ff4-32d59edf3917), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/caffeine/dihydrocodeine | Disulfiram | |
|---|---|---|
| Labeled for | Pain | Alcohol use disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $1.82 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once