What the FDA labels say about taking them together
Acetaminophen/caffeine/dihydrocodeine and aspirin
Acetaminophen/caffeine/dihydrocodeine's FDA label of May 2, 2022 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name acetaminophen/caffeine/dihydrocodeine. The acetaminophen/caffeine/dihydrocodeine label: “Caffeine may increase the metabolism of other drugs such as phenobarbital and aspirin.”
Check it at the source: the acetaminophen/caffeine/dihydrocodeine FDA label on DailyMed (effective May 2, 2022, Proficient Rx LP); the aspirin FDA label on DailyMed (effective September 9, 2025).
What does the acetaminophen/caffeine/dihydrocodeine label say about aspirin?
Acetaminophen/caffeine/dihydrocodeine label, drug interactionsCaffeine may increase the metabolism of other drugs such as phenobarbital and aspirin.
Source: FDA drug label (Trezix), ANDA204785 (Key Therap), as published by Proficient Rx LP, effective May 2, 2022 (SPL set 45c3c2a1-6a89-471e-b6d4-5a4cd73b987a), via openFDA; the full label on DailyMed
What does the aspirin label say about acetaminophen/caffeine/dihydrocodeine?
Aspirin's label (effective September 9, 2025) does not name acetaminophen/caffeine/dihydrocodeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/caffeine/dihydrocodeine | Aspirin | |
|---|---|---|
| Labeled for | Pain | Pain, Cough and cold, Fever |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0142 per tablet 81 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once