What the FDA labels say about taking them together
Acetaminophen/butalbital and chlordiazepoxide
Acetaminophen/butalbital's FDA label of May 6, 2024 names chlordiazepoxide in its drug interactions section; the chlordiazepoxide label PlainMeds reads does not name acetaminophen/butalbital. The acetaminophen/butalbital label: “Butalbital and acetaminophen may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased …”
Check it at the source: the acetaminophen/butalbital FDA label on DailyMed (effective May 6, 2024, QUAGEN PHARMACEUTICALS LLC); the chlordiazepoxide FDA label on DailyMed (effective December 10, 2025, Chartwell RX, LLC).
What does the acetaminophen/butalbital label say about chlordiazepoxide?
Acetaminophen/butalbital label, drug interactionsButalbital and acetaminophen may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.
Source: FDA drug label (BUTALBITAL and ACETAMINOPHEN), QUAGEN PHARMACEUTICALS LLC, effective May 6, 2024 (SPL set 2eb09253-7f59-401e-afbc-70bb9600fedf), via openFDA; the full label on DailyMed
What does the chlordiazepoxide label say about acetaminophen/butalbital?
Chlordiazepoxide's label (effective December 10, 2025) does not name acetaminophen/butalbital in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Chlordiazepoxide Hydrochloride), Chartwell RX, LLC, effective December 10, 2025 (SPL set dd5f82b0-5a56-4728-941a-c8c2a0d51cc4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/butalbital | Chlordiazepoxide | |
|---|---|---|
| Labeled for | n/a | Anxiety, Alcohol use disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.571 per tablet 50-325 mg tablet | $0.158 per capsule 25 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once