What the FDA labels say about taking them together
Acetaminophen/benzhydrocodone and buprenorphine
Acetaminophen/benzhydrocodone's FDA label of January 7, 2025 names buprenorphine in its drug interactions section; the buprenorphine labels PlainMeds reads (4) do not name acetaminophen/benzhydrocodone. The acetaminophen/benzhydrocodone label: “May reduce the analgesic effect of APADAZ and/or precipitate withdrawal symptoms.”
Check it at the source: the acetaminophen/benzhydrocodone FDA label on DailyMed (effective January 7, 2025, Zevra Therapeutics, Inc.); the buprenorphine FDA label on DailyMed (effective June 5, 2026).
What does the acetaminophen/benzhydrocodone label say about buprenorphine?
Acetaminophen/benzhydrocodone label, drug interactionsClinical Impact: May reduce the analgesic effect of APADAZ and/or precipitate withdrawal symptoms. Intervention: Avoid concomitant use. Examples: butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants
Acetaminophen/benzhydrocodone label, warnings and precautionsAdditionally, avoid the use of mixed agonist/antagonist (e.g., pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including APADAZ.
Source: FDA drug label (APADAZ), Zevra Therapeutics, Inc., effective January 7, 2025 (SPL set 0590d4e5-7107-4015-a6a8-deac14265aa2), via openFDA; the full label on DailyMed
What does the buprenorphine label say about acetaminophen/benzhydrocodone?
Buprenorphine's label (effective June 5, 2026) and its 3 other brand-application labels do not name acetaminophen/benzhydrocodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Buprenorphine HCl), SpecGx LLC, effective June 5, 2026 (SPL set b60d514d-a88a-4fa2-a5b0-30ac29e04973), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/benzhydrocodone | Buprenorphine | |
|---|---|---|
| Labeled for | Pain | Opioid use disorder, Pain |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.277 per tablet 2 mg tablet sl |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once