What the FDA labels say about taking them together
Acetaminophen and metyrapone
Metyrapone's FDA label of May 19, 2026 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name metyrapone. The metyrapone label: “Metopirone on Other Drugs Acetaminophen Metopirone inhibits the glucuronidation of acetaminophen, which may decrease elimination of acetaminophen and lead to increased risk of adverse reactions related to acetaminophen.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the metyrapone FDA label on DailyMed (effective May 19, 2026, ESTEVE PHARMACEUTICALS, S.A.).
What does the acetaminophen label say about metyrapone?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name metyrapone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the metyrapone label say about acetaminophen?
Metyrapone label, drug interactionsMetopirone on Other Drugs Acetaminophen Metopirone inhibits the glucuronidation of acetaminophen, which may decrease elimination of acetaminophen and lead to increased risk of adverse reactions related to acetaminophen.
Source: FDA drug label (Metopirone), ESTEVE PHARMACEUTICALS, S.A., effective May 19, 2026 (SPL set 4046b167-7a46-8f4a-e063-6394a90a147f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Metyrapone | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once