What the FDA labels say about taking them together
Acetaminophen and insulin glargine/lixisenatide
Insulin glargine/lixisenatide's FDA label of March 18, 2026 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name insulin glargine/lixisenatide.
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the insulin glargine/lixisenatide FDA label on DailyMed (effective March 18, 2026, Sanofi-Aventis U.S. LLC).
What does the acetaminophen label say about insulin glargine/lixisenatide?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name insulin glargine/lixisenatide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the insulin glargine/lixisenatide label say about acetaminophen?
Insulin glargine/lixisenatide label, drug interactionsOral contraceptives and other medications such as antibiotics and acetaminophen should be taken at least 1 hour prior to SOLIQUA 100/33 administration or 11 hours after.
Source: FDA drug label (Soliqua 100/33), Sanofi-Aventis U.S. LLC, effective March 18, 2026 (SPL set 4bba538b-cf7c-4310-ae8f-cb711ed21bcc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Insulin glargine/lixisenatide | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Type 2 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $57.06 per mL 100 unit-33 mcg/mL pen |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once