What the FDA labels say about taking them together
Acetaminophen and ethinyl estradiol/segesterone
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025).
What does the acetaminophen label say about ethinyl estradiol/segesterone?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/segesterone label say about acetaminophen?
Ethinyl estradiol/segesterone label, drug interactionsAscorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Ethinyl estradiol/segesterone | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Birth control |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $2,315.29 per ring Annovera vaginal ring |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once