What the FDA labels say about taking them together
Acetaminophen and ethinyl estradiol/ferrous fumarate/norethindrone
Ethinyl estradiol/ferrous fumarate/norethindrone's FDA label (Lo Loestrin Fe) of March 7, 2025 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name ethinyl estradiol/ferrous fumarate/norethindrone. The ethinyl estradiol/ferrous fumarate/norethindrone label: “Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the ethinyl estradiol/ferrous fumarate/norethindrone FDA label on DailyMed (effective May 21, 2026, PD-Rx Pharmaceuticals, Inc.).
What does the acetaminophen label say about ethinyl estradiol/ferrous fumarate/norethindrone?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name ethinyl estradiol/ferrous fumarate/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/ferrous fumarate/norethindrone label say about acetaminophen?
Lo Loestrin Fe label (Allergan, Inc., March 7, 2025), drug interactionsAscorbic acid and acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation.
Source: FDA drug label (Lo Loestrin Fe, NDA022501), Allergan, Inc., effective March 7, 2025 (SPL set c33072cf-625d-4b4a-981e-ec049c5d78aa), via openFDA
Source: FDA drug label (Taytulla, NDA204426), Allergan, Inc., effective October 25, 2024 (SPL set 2fa8e8dc-f7b0-429a-b554-0e3c4291c92c), via openFDA
Source: FDA drug label (Junel Fe 28 Day), ANDA076081 (Barr), as published by PD-Rx Pharmaceuticals, Inc., effective May 21, 2026 (SPL set 93a2f8c9-3550-42ec-8f76-3ac9badf4bb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Ethinyl estradiol/ferrous fumarate/norethindrone | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Birth control, Acne |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $0.142 per tablet 1.5-30 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once