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What the FDA labels say about taking them together

Acetaminophen and ethinyl estradiol/ferrous bisglycinate/levonorgestrel

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel's FDA label of January 9, 2025 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel. The ethinyl estradiol/ferrous bisglycinate/levonorgestrel label: “Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.”

Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the ethinyl estradiol/ferrous bisglycinate/levonorgestrel FDA label on DailyMed (effective January 9, 2025, Lupin Pharmaceuticals, Inc.).

What does the acetaminophen label say about ethinyl estradiol/ferrous bisglycinate/levonorgestrel?

Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed

What does the ethinyl estradiol/ferrous bisglycinate/levonorgestrel label say about acetaminophen?

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel label, drug interactions

Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.

Source: FDA drug label (MINZOYA), Lupin Pharmaceuticals, Inc., effective January 9, 2025 (SPL set d5ebd7fa-c388-4619-8dcb-e862e4ce5285), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

89Acetaminophen generic labelers
1Ethinyl estradiol/ferrous bisglycinate/levonorgestrel generic labelers
AcetaminophenEthinyl estradiol/ferrous bisglycinate/levonorgestrel
Labeled forFever, Cough and cold, PainBirth control
Boxed warningYesYes
Pharmacy cost (NADAC)$0.0339 per unit 500 mg caplet$3.45 per tablet 28 tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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