What the FDA labels say about taking them together
Acetaminophen and drospirenone/ethinyl estradiol/levomefolate
Drospirenone/ethinyl estradiol/levomefolate's FDA label of March 4, 2026 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name drospirenone/ethinyl estradiol/levomefolate. The drospirenone/ethinyl estradiol/levomefolate label: “Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the drospirenone/ethinyl estradiol/levomefolate FDA label on DailyMed (effective March 4, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the acetaminophen label say about drospirenone/ethinyl estradiol/levomefolate?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name drospirenone/ethinyl estradiol/levomefolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the drospirenone/ethinyl estradiol/levomefolate label say about acetaminophen?
Drospirenone/ethinyl estradiol/levomefolate label, drug interactionsAscorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.
Source: FDA drug label (Safyral), Bayer HealthCare Pharmaceuticals Inc., effective March 4, 2026 (SPL set 97563516-306a-4e17-9690-edbda49ecd83), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Drospirenone/ethinyl estradiol/levomefolate | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Birth control, Acne |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $1.38 per unit 3-0.02-0.451 |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once