What the FDA labels say about taking them together
Acetaminophen and diclofenac
Diclofenac's FDA label (Licart) of April 2, 2026 names acetaminophen in its warnings and precautions section; the acetaminophen labels PlainMeds reads (4) do not name diclofenac.
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC).
What does the acetaminophen label say about diclofenac?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name diclofenac in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the diclofenac label say about acetaminophen?
Licart label (IBSA Pharma Inc., April 2, 2026), warnings and precautionsExercise caution when prescribing LICART with concomitant drugs that are known to be potentially hepatotoxic (e.g., acetaminophen, antibiotics, anti-epileptics).
Source: FDA drug label (Licart, NDA206976), IBSA Pharma Inc., effective April 2, 2026 (SPL set 851c8b39-6056-4bbc-812e-b9b13977c1ac), via openFDA
Source: FDA drug label (Flector, NDA021234), IBSA Pharma Inc., effective October 21, 2025 (SPL set 1f19a016-c4fc-43c5-9990-e5f2e2776a82), via openFDA
Source: FDA drug label (Zipsor, NDA022202), Assertio Specialty Pharmaceuticals LLC, effective March 1, 2026 (SPL set ed2a8868-78eb-47b8-8f46-0f70e2891e07), via openFDA
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Diclofenac | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $0.0619 per tablet 75 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once